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中部大学 新谷研究室 Advent Calendar 2025:サルコメア動態(HSOs/S4C)と Chaordic Homeodynamics Advent Calendar 2025

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中部大学 新谷研究室 / Shintani Lab, Chubu University

中部大学 新谷研究室/Shintani Lab。心筋サルコメア動態(HSOs/S4C)とChaordic Homeodynamicsを探究。SL-nanometryやDET膜法などの実験系開発、AI2LというコンセプトのAI活用を核に、Python/Colabで再現可能な計測・解析を公開。教育・共同研究を歓迎。


中部大学 新谷研究室/Shintani Lab。心筋サルコメア動態(HSOs/S4C)と Chaordic Homeodynamics(周期×カオス) を中心に、SL‑nanometry や DET膜法などの実験系、SPOC/波動・非線形ダイナミクスの理論・解析、Ti 表面改質や CaTiO₃ 系の医工学応用までを横断しています。

本アドベントカレンダーは、筆者(新谷)が主著または共著として発表した査読付き原著論文 25 報を、1 日 1 本ずつ取り上げて解説します。各回では、背景・方法・主要結果・生理/工学的意義を正確性第一で要約し、分野外の方にも読み進めやすい形で整理します。記事末尾には DOI と推奨引用情報を付し、原著論文を紹介します。

  • 第1章|計測技術の礎(Day 01–05)
    SL nanometry/Ca+SL同時計測/in vivo ナノ・イメージング/温度ナノシート/DET膜リアルタイムSEM
  • 第2章|サルコメア振動と波の発見(Day 06–10)
    加熱誘起HSO/熱パルス活性化/SPOC波モデル/心壁伝搬波/Lamb波分散
  • 第3章|モデルと相互作用(Day 11–15)
    3状態パワーストローク/受動弾性と力の通信/液晶的バイオモーション/高圧効果/リズム恒常性
  • 第4章|カオスとホメオダイナミクス(Day 16–18)
    温度×カオス/Ca²⁺×カオス/位相・振幅解析(“hole”挙動)
  • 第5章|応用と医工融合(Day 19–24)
    薄フィラメント制御とFrank–Starling / Ti表面改質・CaTiO₃・ヨウ素放出・骨再生
  • フィナーレ(Day 25)
    Chaordic Homeodynamics の総括

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Series 1

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30
Zディスク蛍光でサルコメア長をnm精度で測る(SL-nanometry入門)

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Ca²⁺局所と単一サルコメア長を同時に観る:YC‑Nano140

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拍動心で“ナノ”を測る:in vivo cardiac nano‑imaging

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細胞1枚の温度地図:蛍光温度計ナノシート

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濡れたまま観察:DET膜によるリアルタイムSEM

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温めると現れるHSOs:加熱誘起の高周波自発振動

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顕微熱パルスが薄いフィラメントを起動する

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SPOC波をどう再現するか:束化筋原線維のモデル化

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拡張期の心壁を走る波:超音波計測とモデル

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心壁パルス波を記述する:Lamb波の単純分散式

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“隣のサルコメア”に伝わる:受動弾性とメカニカル通信

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3状態パワーストロークモデルで読む自発振動

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バイオモーションは“液晶的”か:動的性質の俯瞰

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HSOsのリズム恒常性:なぜ周期は守られるのか

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高圧をかけると何が変わる?筋原線維の構造と機能

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周期は一定・振幅はカオス:高温HSOsの振る舞い

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Ca²⁺で誘発されるサルコメア・カオスの観測

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Hilbert解析で見える“hole”:位相と振幅が語る波の像

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アクチンフィラメント制御とFrank–Starling機構の整理

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チタンにカルシウム欠損CaTiO₃:三機能コーティングの設計

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SLM製チタンの混酸+加熱処理:前骨芽細胞分化を促進

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ヨウ素担持CaTiO₃:持続抗菌と骨修復の両立

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薬剤放出ゼラチン×CaTiO₃で骨粗鬆症骨修復を狙う

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勾配多孔チタン+ヨウ素徐放:力学・生体活性・長期抗菌の統合

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Chaordic Homeodynamics:サルコメア“周期×カオス”の生理的意義

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2627
  1. Zディスク蛍光でサルコメア長をnm精度で測る(SL-nanometry入門)

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  2. Ca²⁺局所と単一サルコメア長を同時に観る:YC‑Nano140

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  3. 拍動心で“ナノ”を測る:in vivo cardiac nano‑imaging

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  4. 細胞1枚の温度地図:蛍光温度計ナノシート

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  5. 濡れたまま観察:DET膜によるリアルタイムSEM

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  6. 温めると現れるHSOs:加熱誘起の高周波自発振動

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  7. 顕微熱パルスが薄いフィラメントを起動する

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  8. SPOC波をどう再現するか:束化筋原線維のモデル化

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  9. 拡張期の心壁を走る波:超音波計測とモデル

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  10. 心壁パルス波を記述する:Lamb波の単純分散式

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  11. “隣のサルコメア”に伝わる:受動弾性とメカニカル通信

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  12. 3状態パワーストロークモデルで読む自発振動

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  13. バイオモーションは“液晶的”か:動的性質の俯瞰

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  14. HSOsのリズム恒常性:なぜ周期は守られるのか

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  15. 高圧をかけると何が変わる?筋原線維の構造と機能

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  16. 周期は一定・振幅はカオス:高温HSOsの振る舞い

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  17. Ca²⁺で誘発されるサルコメア・カオスの観測

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  18. Hilbert解析で見える“hole”:位相と振幅が語る波の像

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  19. アクチンフィラメント制御とFrank–Starling機構の整理

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  20. チタンにカルシウム欠損CaTiO₃:三機能コーティングの設計

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  21. SLM製チタンの混酸+加熱処理:前骨芽細胞分化を促進

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  22. ヨウ素担持CaTiO₃:持続抗菌と骨修復の両立

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  23. 薬剤放出ゼラチン×CaTiO₃で骨粗鬆症骨修復を狙う

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  24. 勾配多孔チタン+ヨウ素徐放:力学・生体活性・長期抗菌の統合

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  25. Chaordic Homeodynamics:サルコメア“周期×カオス”の生理的意義

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SundayMondayTuesdayWednesdayThursdayFridaySaturday
30
Zディスク蛍光でサルコメア長をnm精度で測る(SL-nanometry入門)

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Ca²⁺局所と単一サルコメア長を同時に観る:YC‑Nano140

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拍動心で“ナノ”を測る:in vivo cardiac nano‑imaging

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細胞1枚の温度地図:蛍光温度計ナノシート

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濡れたまま観察:DET膜によるリアルタイムSEM

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温めると現れるHSOs:加熱誘起の高周波自発振動

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顕微熱パルスが薄いフィラメントを起動する

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SPOC波をどう再現するか:束化筋原線維のモデル化

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拡張期の心壁を走る波:超音波計測とモデル

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心壁パルス波を記述する:Lamb波の単純分散式

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“隣のサルコメア”に伝わる:受動弾性とメカニカル通信

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3状態パワーストロークモデルで読む自発振動

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バイオモーションは“液晶的”か:動的性質の俯瞰

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HSOsのリズム恒常性:なぜ周期は守られるのか

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高圧をかけると何が変わる?筋原線維の構造と機能

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周期は一定・振幅はカオス:高温HSOsの振る舞い

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Ca²⁺で誘発されるサルコメア・カオスの観測

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Hilbert解析で見える“hole”:位相と振幅が語る波の像

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アクチンフィラメント制御とFrank–Starling機構の整理

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チタンにカルシウム欠損CaTiO₃:三機能コーティングの設計

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SLM製チタンの混酸+加熱処理:前骨芽細胞分化を促進

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ヨウ素担持CaTiO₃:持続抗菌と骨修復の両立

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薬剤放出ゼラチン×CaTiO₃で骨粗鬆症骨修復を狙う

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勾配多孔チタン+ヨウ素徐放:力学・生体活性・長期抗菌の統合

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Chaordic Homeodynamics:サルコメア“周期×カオス”の生理的意義

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2627
  1. Zディスク蛍光でサルコメア長をnm精度で測る(SL-nanometry入門)

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  2. Ca²⁺局所と単一サルコメア長を同時に観る:YC‑Nano140

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  3. 拍動心で“ナノ”を測る:in vivo cardiac nano‑imaging

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  4. 細胞1枚の温度地図:蛍光温度計ナノシート

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  5. 濡れたまま観察:DET膜によるリアルタイムSEM

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  6. 温めると現れるHSOs:加熱誘起の高周波自発振動

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  7. 顕微熱パルスが薄いフィラメントを起動する

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  8. SPOC波をどう再現するか:束化筋原線維のモデル化

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  9. 拡張期の心壁を走る波:超音波計測とモデル

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  10. 心壁パルス波を記述する:Lamb波の単純分散式

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  11. “隣のサルコメア”に伝わる:受動弾性とメカニカル通信

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  12. 3状態パワーストロークモデルで読む自発振動

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  13. バイオモーションは“液晶的”か:動的性質の俯瞰

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  14. HSOsのリズム恒常性:なぜ周期は守られるのか

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  15. 高圧をかけると何が変わる?筋原線維の構造と機能

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  16. 周期は一定・振幅はカオス:高温HSOsの振る舞い

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  17. Ca²⁺で誘発されるサルコメア・カオスの観測

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  18. Hilbert解析で見える“hole”:位相と振幅が語る波の像

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  19. アクチンフィラメント制御とFrank–Starling機構の整理

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  20. チタンにカルシウム欠損CaTiO₃:三機能コーティングの設計

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  21. SLM製チタンの混酸+加熱処理:前骨芽細胞分化を促進

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  22. ヨウ素担持CaTiO₃:持続抗菌と骨修復の両立

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  23. 薬剤放出ゼラチン×CaTiO₃で骨粗鬆症骨修復を狙う

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  24. 勾配多孔チタン+ヨウ素徐放:力学・生体活性・長期抗菌の統合

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  25. Chaordic Homeodynamics:サルコメア“周期×カオス”の生理的意義

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