環境
macOS Sierra(10.12)
mysql2
gem 'mysql2'
エラー
Gem::Ext::BuildError: ERROR: Failed to build gem native extension.
/Users/saicologic/.rbenv/versions/2.1.6/bin/ruby extconf.rb
checking for ruby/thread.h... yes
checking for rb_thread_call_without_gvl() in ruby/thread.h... yes
checking for rb_thread_blocking_region()... yes
checking for rb_wait_for_single_fd()... yes
checking for rb_hash_dup()... yes
checking for rb_intern3()... yes
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Using mysql_config at /usr/local/bin/mysql_config
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checking for mysql.h... yes
checking for errmsg.h... yes
checking for mysqld_error.h... yes
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Don't know how to set rpath on your system, if MySQL libraries are not in path mysql2 may not load
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Setting libpath to /usr/local/Cellar/mysql/5.7.16/lib
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creating Makefile
make "DESTDIR=" clean
make "DESTDIR="
compiling client.c
compiling infile.c
compiling mysql2_ext.c
compiling result.c
linking shared-object mysql2/mysql2.bundle
ld: library not found for -lssl
clang: error: linker command failed with exit code 1 (use -v to see invocation)
make: *** [mysql2.bundle] Error 1
make failed, exit code 2
解決
$ bundle config --local build.mysql2 "--with-ldflags=-L/usr/local/opt/openssl/lib --with-cppflags=-I/usr/local/opt/openssl/include"
参考：http://stackoverflow.com/questions/39617761/cant-install-mysql2-gem-on-macos-sierra