Nginx で Mautic を使うための Config 設定です。
location 内の設定のみですので、その他のチューニングはお願いします。

Amazon Linux 2 & Nginx + PHP7.2 で動作確認をしました (2019年3月)
パスは /var/www/EXAMPLE.COM を変えてください
server_name EXAMPLE.COM; を適宜変えて下さい
ログの保存先を適宜変えてください。
適宜 SSL 証明書の設定を追加して下さい。

/etc/nginx/conf.d/10_vhosts_example.com.conf

server {
    listen       80;
    listen       [::]:80;
    listen       443 ssl http2;
    listen       [::]:443 ssl http2;

    server_name  EXAMPLE.COM;
    add_header Strict-Transport-Security "max-age=31536000; includeSubDomains";

	charset      utf-8;
	client_max_body_size 32m;

    access_log   /var/log/nginx/EXAMPLE.COM-access.log main;
    error_log    /var/log/nginx/EXAMPLE.COM-error.log warn;

    root         /var/www/vhosts/EXAMPLE.COM;
    location /.well-known {
        # dont-send to php we need it open for lets encrypt
        # try if it exists, if not redirect back to index.php
        auth_basic off;
        try_files $uri / index.php;
    }

	gzip_vary on;
	gzip_disable msie6;
	gzip_static on;
	gzip_comp_level 9;
 	gzip_proxied any;
	gzip_types text/plain text/css application/x-javascript text/xml application/xml application/xml+rss text/javascript;

    location / {
    	index  index.php;
        try_files $uri $uri/ /index.php?$query_string;
    }

	# Deny access to any files with a .php extension in the uploads directory
    location ~* /(?:uploads|files)/.*\.php$ {
            deny all;
    }

    # Solve email tracking pixel not found
    location ~ email/(.*).gif {
        try_files $uri /index.php?$args;
    }
    # Solve JS Loading 404 Error
    location ~ (.*).js {
        try_files $uri /index.php?$args;
    }

    location ~* \.(jpg|jpeg|gif|png|css|js|ico)$ {
        access_log        off;
        log_not_found     off;
        expires           8d;
    }

    # Don't output hidden files
    location ~ /\.git {
        return 404;
    }
    location ~ /\.ht {
        return 404;
    }

    location ~ \.php($|/) {

		fastcgi_split_path_info ^(.+\.php)(/.+)$;
		fastcgi_pass  unix:/var/run/php-fpm/www.sock;
		fastcgi_index index.php;
		fastcgi_param URI $uri;
		fastcgi_param SERVER_NAME $host;
		fastcgi_param REQUEST_METHOD $request_method;
		fastcgi_param SCRIPT_FILENAME $document_root$fastcgi_script_name;
		fastcgi_read_timeout 300;
		fastcgi_ignore_headers Expires Cache-Control;
		
		fastcgi_cache_bypass 1;
		fastcgi_no_cache     1;
		fastcgi_cache        fastcgi_cache;
		fastcgi_cache_valid  any 1m;
    }
}

参考記事